Related Experiment Video
Updated: Jan 31, 2026
11:46
Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
Published on: April 27, 2014
18.4K
GAG replenishment therapy for bladder pain syndrome/interstitial cystitis
Jean Jacques J Wyndaele1, Claus Riedl2, Rajesh Taneja3
1Universiteit Antwerpen, Antwerp, Belgium.
Neurourology and Urodynamics
|December 29, 2018
Summary
Glycosaminoglycan (GAG) replenishment therapy can help restore the bladder
Area of Science:
- Urology
- Cell Biology
- Biochemistry
Background:
- The urothelial glycosaminoglycan (GAG) layer is crucial for bladder permeability and protection.
- Dysfunction of the GAG layer is implicated in the pathogenesis of bladder pain syndrome/interstitial cystitis (BPS/IC).
- Current understanding suggests GAG layer disruption contributes to BPS/IC development.
Purpose of the Study:
- To establish the rationale for including urothelial coating dysfunction in BPS/IC pathogenesis.
- To review preclinical and clinical evidence for GAG replenishment therapy in BPS/IC.
- To incorporate expert and patient advocate experiences from ESSIC'17.
Main Methods:
- Review of preclinical and clinical studies on GAG replenishment.
- Synthesis of expert opinions and patient advocate experiences.
- Symposium discussion at ESSIC'17 in Budapest, Hungary.
Main Results:
- Evidence indicates GAG replenishment can restore the urothelial GAG layer in BPS/IC.
- Restoration of the GAG layer leads to reduced inflammation, pain, and other BPS/IC symptoms.
- GAG replenishment therapy demonstrates potential for symptom relief in BPS/IC patients.
Conclusions:
- Intravesical GAG replenishment therapy offers symptomatic relief for BPS/IC.
- Clinical observations and expert experience support its efficacy.
- Further large-scale randomized controlled studies are warranted.
Related Concept Videos
01:23Urinary Bladder
3.4K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
3.4K
01:20Pain
1.4K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
1.4K
00:59Gene Therapy
27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
01:19Anatomy of the Genitourinary System II: Bladder and Urethra
1.6K
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
1.6K
01:26Group Therapy
434
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
434
01:24Nephrotic Syndrome I : Introduction
633
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
633