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Updated: Jan 31, 2026
20:38
Isolation and Transplantation of Hematopoietic Stem Cells HSCs
Published on: February 25, 2007
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Haematopoietic stem cell transplants: principles and indications
Katalin Balassa1, Robert Danby2, Vanderson Rocha3
1Clinical Research Fellow in Bone Marrow Transplantation, Oxford University Hospitals NHS Foundation Trust, Department of Clinical Haematology, Cancer and Haematology Centre, Churchill Hospital, Headington, Oxford OX3 7LE and NHS Blood and Transplant, Oxford.
British Journal of Hospital Medicine (London, England : 2005)
|December 29, 2018
Summary
Haematopoietic stem cell transplantation (HSCT) offers a potential cure for various conditions. This established treatment is increasingly used for high-risk autoimmune diseases by resetting the immune system.
Area of Science:
- Immunology
- Hematology
- Transplantation Medicine
Background:
- Haematopoietic stem cell transplantation (HSCT) has evolved from a proposed strategy to an established treatment over 60 years.
- Over one million HSCT procedures were performed globally by 2012 for hemato-oncological, immunological, and hereditary conditions.
- HSCT offers potential cures for a range of serious diseases.
Purpose of the Study:
- To provide an overview of autologous and allogeneic HSCT.
- To detail disease indications, procedural steps, and outcomes.
- To highlight HSCT advancements in treating autoimmune diseases.
Main Methods:
- Review of existing literature on HSCT procedures and outcomes.
- Analysis of disease indications for both autologous and allogeneic HSCT.
- Focus on the application and efficacy of HSCT in autoimmune conditions.
Main Results:
- HSCT is increasingly utilized for high-risk autoimmune diseases, despite accounting for only 1% of autologous HSCT indications.
- The procedure can induce long-term remission by eradicating autoreactive immune cells and generating a new self-tolerant immune system.
- Encouraging results are observed in treating multiple sclerosis and systemic sclerosis.
Conclusions:
- HSCT is a powerful therapeutic option with a significant impact on treating various diseases.
- The use of HSCT for autoimmune diseases is growing, particularly for conditions like multiple sclerosis and systemic sclerosis.
- Future trends suggest an increased number of HSCT procedures for autoimmune conditions.
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