[Antiplatelet activity of flavonoids]

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Flavonoid Content During the Growth and Floral Development of Calendula officinalis L.
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Ya F Zverev1

  • 1Altai State Medical University, Barnaul.

Voprosy Pitaniia
|December 29, 2018
PubMed

Insights

Flavonoids, potent plant polyphenols, show promise in cardiovascular health by modulating platelet function. Further research is needed to translate in vitro findings into effective antiplatelet therapies.

Area of Science:

  • Nutritional Biochemistry
  • Cardiovascular Pharmacology
  • Phytochemistry

Context:

  • Cardiovascular diseases (CVDs) remain a leading cause of mortality worldwide.
  • Dietary factors, particularly polyphenolic compounds like flavonoids, are increasingly recognized for their health benefits.
  • Platelets play a critical role in hemostasis and thrombosis, making them key targets for CVD prevention.

Purpose:

  • To review the influence of major food flavonoid subclasses on the organism.
  • To discuss the role of flavonoids and flavonoid-rich foods in reducing cardiovascular disease risk.
  • To analyze the mechanisms by which flavonoids affect platelet function, including activation, adherence, and aggregation.

Summary:

  • Flavonoids, a diverse group of plant polyphenols found in food, exert significant effects on organismal health.
  • Evidence suggests flavonoids can correct platelet abnormalities by interacting with various receptors and intracellular signaling pathways.
  • These compounds influence key steps in platelet activation, such as calcium mobilization and signal transduction.

Impact:

  • Flavonoids demonstrate potential as a basis for developing safe and effective antiplatelet agents.
  • This research highlights the contribution of flavonoids to the treatment and prevention of cardiovascular diseases.
  • Acknowledges the need for further in vivo studies to bridge the gap between in vitro findings and clinical application.
Keywords:
flavonoidsmechanisms of direct and indirect effectsplatelet aggregation

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