[SPECIFIC FEATURES AND PROSPECTS OF THE PHARMACOKINETIC STUDY OF HISTOCHROME.]

The review summarizes available data on the pharmacokinetics of new Russian drug histochrome, the active substance in which is a quinoid pigment of marine invertebrates, echinochrome A (2,3,5,6,8-pentahydroxy-7-ethyl-1,4-naphthoquinone). Based on the modem notions about close connection of the pharmacoki- netics and pharmacodynamics of drugs, the authors consider prospects for studying the histochrome pharmacokinetics, including the issues of echinochrome A metabolism and the probability of formation of a biologically active metabolite. In assessing the pharmacokinetic aspects of the new drug, the authors draw at- tention of researchers to profound study of histochrome administration schemes and dosing regime in the context of improving its therapeutic applications.