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Use of Enzymatic Biosensors to Quantify Endogenous ATP or H2O2 in the Kidney
Published on: October 12, 2015
Activation of P-450-Dependent Monooxygenases Modulates the Diuretic Effect of Histochrome in Rats
O S Talalaeva1, V M Bryukhanov2, Ya F Zverev2
1Department of Pharmacology, Altay State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia. talalaeva_olga@mail.ru.
Abstract:
We studied the role of the liver monooxygenase system in pharmacological activity of histochrome, a pharmaceutical form of echinochrome A. In experiments on rats, benzonal, an inductor of the monooxygenase system of phenobarbytal type, significantly potentiated the diuretic effect of histochrome. Benzonal withdrawal was followed by a natriuretic reaction. In view of the known inverse relation between the biological effect of the drug and the rate of its metabolism, our findings suggest that the effects of echinochrome A on some kidney excretory function parameters are produced not by native agent, but one of its metabolites.
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