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Developmental Requirement of Homeoprotein Otx2 for Specific Habenulo-Interpeduncular Subcircuits

Nuria Ruiz-Reig1, Malalaniaina Rakotobe1, Ingrid Bethus2

  • 1Université Côte d'Azur, Centre National de la Recherche Scientifique, Inserm, Institut de Biologie Valrose, 06108 Nice, France, and.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|December 30, 2018
PubMed
Summary

The Otx2 gene is crucial for the development of the habenulo-interpeduncular system (HIPS), a key brain reward circuit. Its absence disrupts HIPS formation and connectivity, potentially modeling psychiatric disorders.

Keywords:
circuits formationgenetic modelshomeoproteinneuronal migrationpsychiatric diseasesreward circuits

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