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Updated: Jan 31, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
Idiopathic pulmonary fibrosis coexisting with lung cancer - a review
Michał Zieliński1, Piotr Sitek, Dariusz Ziora
1Katedra i Klinika Chorób Płuc i Grużlicy, Wydział Lekarski z Oddziałem Lekarsko-dentystycznym w Zabrzu. Śląskiego Uniwersytetu Medycznego w Katowicach Department of Lung Diseases and Tuberculosis, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Poland. michal.zielinski1@interia.pl.
Abstract:
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease with poor prognosis. Although the underlying mechanisms are not fully understood, IPF is connected with lung cancer development, which farther worsens the prognosis. Various papers report IPF and cancer coexistence in 9.8% to even 82% of patients depending on observation period. Contrary to already established guidelines in the general population, there are no widely accepted recommendations on lung cancer treatment in IPF population. At the same time, various oncologic interventions can result in acute exacerbation of IPF. This paper tries to revise the available data on lung cancer in patients with preexisting IPF.
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