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Updated: Jan 31, 2026
08:36
Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI
Published on: July 12, 2012
15.5K
Manganese Transport into the Brain: Putative Mechanisms
Michael Aschner1, Ana Paula Marreilha Dos Santos2, Keith M Erikson3
1Department of Pediatrics, Pharmacology, and the Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, Nashville, TN, USA, michael.aschner@vanderbilt.edu.
Metal Ions in Biology and Medicine : Proceedings of the ... International Symposium on Metal Ions in Biology and Medicine Held ... = Les Ions Metalliques En Biologie Et En Medecine : ... Symposium International Sur Les Ions Metalliques
|January 1, 2019
Summary
Manganese (Mn) transport across the blood-brain barrier (BBB) is key to brain accumulation. This review explores Mn distribution in the central nervous system (CNS), focusing on iron (Fe) interactions and transport proteins like transferrin (Tf) and divalent metal transporter 1 (DMT1).
Area of Science:
- Neuroscience
- Toxicology
- Biochemistry
Background:
- Metal transport across the blood-brain barrier (BBB) is critical for understanding neurotoxic effects.
- Manganese (Mn) accumulation in the brain is a significant toxicologic concern.
- The BBB's capillary endothelial cells regulate substance entry into the central nervous system (CNS).
Purpose of the Study:
- To review known transport mechanisms of manganese (Mn) across the blood-brain barrier (BBB).
- To discuss the distribution of Mn within the CNS.
- To identify potential Mn transport pathways, emphasizing interactions with iron (Fe) and specific transporters.
Main Methods:
- Literature review of Mn transport across the BBB.
- Analysis of Mn distribution in the CNS.
- Examination of the chemical interactions between Mn and Fe.
- Investigation of the roles of transferrin (Tf) and divalent metal transporter 1 (DMT1) in Mn transport.
Main Results:
- Mn transport across the BBB is a crucial step in its brain accumulation.
- Mn distribution within the CNS is influenced by specific transport mechanisms.
- A close chemical relationship exists between Mn and Fe.
- Transferrin (Tf) and divalent metal transporter 1 (DMT1) are implicated in Mn transport.
Conclusions:
- Understanding Mn transport across the BBB is vital for assessing its neurotoxicity.
- The interplay between Mn, Fe, Tf, and DMT1 significantly influences Mn's CNS distribution and potential toxicity.
- Further research into these transport mechanisms can inform strategies for mitigating Mn-induced neurotoxicity.
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