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Updated: Jan 31, 2026
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Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
Published on: February 25, 2021
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Enhanced nanoparticle delivery exploiting tumour-responsive formulations.
Lindsey A Bennie1, Helen O McCarthy1, Jonathan A Coulter1
1School of Pharmacy, Queens University Belfast, Lisburn Road, Belfast, BT9 7BL UK.
Cancer Nanotechnology
|January 1, 2019
Summary
Nanoparticle drug delivery for cancer can be improved by exploiting the tumor microenvironment. Strategies focus on enhancing nanoparticle stability, biodistribution, and cell internalization for better therapeutic outcomes.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Nanoparticles offer potential as drug carriers, contrast agents, and radiosensitizers for cancer treatment.
- Passive accumulation via the enhanced permeability and retention effect favors nanoparticles <150 nm in tumor sites.
- Clinical translation challenges include poor in vivo stability, biodistribution, and target cell internalization.
Purpose of the Study:
- To review strategies for tumor microenvironment (TME) targeting to improve nanoparticle delivery.
- To focus on the delivery of nucleic acids and gold nanoparticles within the TME.
- To critically evaluate evidence for key research areas and future technologies in nanoparticle-based cancer therapy.
Main Methods:
- Review of existing literature on nanoparticle-based cancer therapeutics.
- Analysis of strategies exploiting TME features like hypoxia, pH, and extracellular matrix.
- Evaluation of advanced delivery systems including cell-penetrating peptides and responsive stealth molecules.
Main Results:
- Nanoparticle modification can exploit TME characteristics, unlike traditional chemotherapies, potentially reducing systemic toxicities.
- Targeting strategies aim to overcome limitations in in vivo stability, biodistribution, and cellular uptake.
- Next-generation cell-penetrating peptides and responsive stealth molecules show promise for enhanced delivery.
Conclusions:
- Exploiting the TME offers a promising avenue for improving nano-therapeutic efficacy and safety.
- Advanced nanoparticle designs are crucial for overcoming current clinical translation barriers.
- Future research should focus on developing innovative delivery systems that leverage TME-specific properties.
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