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Sleep and Memory Disorders in a Patient Suffering from Charcot-Marie-Tooth Disease

C Florescu1, C V Albu2, C Dumitrescu3

  • 1Department of Cardiology, University of Medicine and Pharmacy of Craiova, Romania.

Current Health Sciences Journal
|January 1, 2019
PubMed

Insights

Charcot-Marie-Tooth disease, a common inherited neurological disorder, can manifest with sleep, memory, and attention issues. This case highlights a patient with CMT and diabetes, emphasizing sensory loss and infection risks.

Area of Science:

  • Neurology
  • Genetics

Background:

  • Charcot-Marie-Tooth (CMT) disease is the most prevalent inherited neurological disorder, currently without a cure.
  • The primary genetic cause is PMP22 gene duplication on chromosome 17.
  • CMT affects a small but significant portion of the population.

Purpose of the Study:

  • To report a unique case of Charcot-Marie-Tooth disease presenting with cognitive and sleep disturbances.
  • To explore the potential interplay between CMT, diabetes mellitus, and associated complications.

Main Methods:

  • Case report of a 37-year-old male patient diagnosed with CMT.
  • Clinical assessment including neurological examination and review of medical history.
  • Analysis of patient's comorbidities, specifically diabetes mellitus.

Main Results:

  • The patient exhibited sleep, memory, and attention deficits, including early-onset retrograde amnesia.
  • No family history of genetic disease was reported.
  • The patient was diagnosed with diabetes mellitus, correlating with sensory loss and prolonged infections.

Conclusions:

  • This case underscores the diverse clinical manifestations of CMT, extending beyond peripheral neuropathy to include cognitive and sleep disorders.
  • The presence of diabetes mellitus exacerbates sensory symptoms and increases susceptibility to infections with delayed healing in CMT patients.
  • Further research is warranted to understand the complex relationship between CMT, diabetes, and neurological function.
Keywords:
Charcot-Marie-Toothinherited neuromuscular disordersleep disorders

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