Related Experiment Video
Updated: Jan 31, 2026

07:34
Layer Microdissection of Tricuspid Valve Leaflets for Biaxial Mechanical Characterization and Microstructural Quantification
Published on: February 10, 2022
2.4K
Spontaneous leaflet fracture resulting in embolization from mechanical valve prostheses
Gijs G J van Steenbergen1, Queeny H Y Tsang1, Stefan M van der Heide1
1Department of Cardiothoracic Surgery at Radboudumc, Nijmegen, the Netherlands.
Journal of Cardiac Surgery
|January 1, 2019
Summary
Spontaneous leaflet embolization from a mechanical heart valve is rare. This case highlights a potentially life-threatening complication occurring 31 years after aortic valve replacement surgery.
Area of Science:
- Cardiovascular Surgery
- Biomedical Engineering
- Materials Science
Background:
- Mechanical heart valves are crucial for treating valvular heart disease.
- Spontaneous leaflet fracture is an exceedingly rare but serious complication.
- Long-term durability of prosthetic devices is a key concern in cardiac surgery.
Observation:
- A case of spontaneous leaflet embolization is presented.
- The event occurred 31 years after aortic valve replacement.
- The prosthesis involved was an Edwards-Duromedics mechanical heart valve.
Findings:
- The study documents a rare instance of mechanical heart valve leaflet failure.
- Late-onset leaflet embolization can occur even decades after implantation.
- Review of literature supports the rarity and severity of this complication.
Implications:
- Increased awareness among clinicians is crucial for early diagnosis and management.
- This case underscores the need for vigilance regarding long-term prosthetic valve integrity.
- Further research into material fatigue and failure mechanisms in mechanical heart valves is warranted.
Related Concept Videos
Spontaneity
29.8K
A spontaneous process is one that occurs naturally under certain conditions. A nonspontaneous process, on the other hand, will not take place unless it is “driven” by the continual input of energy from an external source. Processes have a natural tendency to occur in one direction under a given set of conditions. Water will naturally flow downhill (spontaneous process), but uphill flow (nonspontaneous process) requires outside intervention such as the use of a pump. Iron exposed to...
29.8K
Pulmonary Embolism I: Introduction
702
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
702
Heart Valves
12.1K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
12.1K
Fractures: Bone Repair
5.4K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
5.4K
Spontaneous and Induced Mutations
2.3K
Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
2.3K
Pulmonary Embolism III: Nursing Management
437
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
437

