Related Experiment Video
Updated: Jan 31, 2026

In vitro Assembly of Semi-artificial Molecular Machine and its Use for Detection of DNA Damage
Published on: January 11, 2012
Understanding molecular mechanisms in cell signaling through natural and artificial sequence variation
Neel H Shah1, John Kuriyan2,3,4,5,6
1Department of Chemistry, Columbia University, New York, NY, USA. neel.shah@columbia.edu.
Abstract:
The functionally tolerated sequence space of proteins can now be explored in an unprecedented way, owing to the expansion of genomic databases and the development of high-throughput methods to interrogate protein function. For signaling proteins, several recent studies have shown how the analysis of sequence variation leverages the available protein-structure information to provide new insights into specificity and allosteric regulation. In this Review, we discuss recent work that illustrates how this emerging approach is providing a deeper understanding of signaling proteins.
Related Concept Videos
Natural and Artificial Concepts
Signal Sequences and Sorting Receptors
What is Cell Signaling?
Conservative Site-specific Recombination and Phase Variation
The recognition sites for Cre recombinase called LoxP...
What is Natural Selection?
What is Variation?
The range, standard deviation, standard error, and variance are the different measures of variation.
Range: The range is the difference between its maximum and...

