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Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing
Georgia Minakaki1, Fabio Canneva2, Frédéric Chevessier3
1Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Behavioural Brain Research
|January 2, 2019
Summary
Treadmill exercise improved gait and postural stability in mice, promoting dopaminergic and alpha-synuclein balance. This study highlights exercise benefits for Parkinson's disease (PD) models.
Area of Science:
- Neuroscience
- Exercise Physiology
- Molecular Biology
Background:
- Parkinson's disease (PD) involves gait and postural control issues, linked to alpha-synuclein buildup and impaired autophagy-lysosome pathway (ALP).
- Physical exercise shows promise for improving PD motor symptoms and may offer neuroprotection.
Purpose of the Study:
- To investigate the effects of treadmill exercise on gait, ALP activity, and dopaminergic/alpha-synuclein homeostasis in mouse models of PD.
- To determine if exercise can restore motor function and central biochemical markers relevant to Parkinson's disease.
Main Methods:
- Four weeks of treadmill exercise in wild type, alpha-synuclein knockout, and human alpha-synuclein transgenic mice.
- Automated gait analysis (CatWalk XT) for regularity, stability, activity, and postural control.
- Biochemical analysis of striatal tyrosine hydroxylase and cerebral alpha-synuclein species, with assessment of cerebral ALP activity.
Main Results:
- Exercise improved gait speed and stride length, enhancing postural support in alpha-synuclein models.
- Biochemical analysis revealed increased dopaminergic markers and reduced aggregated alpha-synuclein in the brain.
- No significant induction of cerebral autophagy-lysosome pathway (ALP) activity was observed post-exercise.
Conclusions:
- Treadmill exercise effectively improved gait and postural stability in PD mouse models.
- Exercise promoted dopaminergic and alpha-synuclein homeostasis, suggesting a neuroprotective effect.
- Cerebral ALP induction was not a significant outcome, indicating exercise benefits may occur through alternative mechanisms.
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