Related Experiment Video

Updated: Jan 31, 2026

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
11:02

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Published on: September 14, 2018

8.2K

Antibody-Drug Conjugates for the Therapy of Thoracic Malignancies

Hao Xie1, Alex A Adjei1

  • 1Mayo Clinic, Rochester, Minnesota.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
|January 2, 2019
PubMed

Insights

Antibody-drug conjugates (ADCs) combine targeted antibodies with cytotoxic drugs for cancer therapy. This review covers ADC design, pharmacology, toxicities, and their development for thoracic malignancies.

Area of Science:

  • Oncology
  • Pharmacology
  • Biotechnology

Background:

  • Antibody-drug conjugates (ADCs) represent a novel therapeutic class combining monoclonal antibodies with cytotoxic agents.
  • ADCs were initially developed for hematologic malignancies, with HER2-targeted ADCs approved for breast cancer.
  • Numerous ADCs are currently being investigated for various solid tumors.

Purpose of the Study:

  • To provide a comprehensive review of antibody-drug conjugates (ADCs).
  • To discuss the design, pharmacology, and toxicities of ADCs.
  • To highlight ADCs in clinical development for thoracic malignancies.

Main Methods:

  • Literature review of antibody-drug conjugates (ADCs).
  • Analysis of ADC design, pharmacology, and mechanism-based toxicities.
  • Examination of ADCs in clinical trials for thoracic cancers.

Main Results:

  • ADCs offer targeted delivery of cytotoxic payloads.
  • HER2-targeted ADCs are established for breast cancer treatment.
  • A growing number of ADCs are in development for diverse solid tumors and thoracic malignancies.

Conclusions:

  • ADCs are a promising therapeutic strategy in oncology.
  • Understanding ADC design and toxicity is crucial for clinical success.
  • Ongoing development holds potential for treating thoracic malignancies.
Keywords:
AntibodyConjugateThoracic malignanciesToxophore

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