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Characteristics of biological therapy in pediatric patients with Crohn's disease

Andras Tarnok1, Zoltan Kiss2,3, Orsolya Kadenczki4

  • 1a Department of Pediatrics, Medical School , University of Pecs , Pécs , Hungary.

Expert Opinion on Biological Therapy
|January 3, 2019
PubMed

Insights

This review summarizes biological drugs for pediatric Crohn

Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Pharmacology

Background:

  • Crohn's disease (CD) in children requires effective treatment strategies.
  • Biologic therapies have emerged as crucial options for managing pediatric CD.
  • A comprehensive understanding of available biologics in this population is needed.

Purpose of the Study:

  • To review and characterize the various biologic drugs used in pediatric patients with Crohn's disease.
  • To provide an overview of current therapeutic approaches and future directions in biologic therapy for pediatric CD.

Main Methods:

  • Systematic literature review of studies on biologic therapies in pediatric Crohn's disease.
  • Analysis of drug mechanisms, pharmacokinetics, efficacy, safety, and cost-effectiveness.
  • Inclusion of new biologic agents, biosimilars, and treatment optimization strategies.

Main Results:

  • Multiple biologic agents are available for pediatric Crohn's disease, targeting different pathways.
  • Data exist on efficacy, safety, and long-term outcomes for several biologics.
  • Gaps in knowledge include a lack of head-to-head comparative studies between different biologics.

Conclusions:

  • Biologic therapy is a cornerstone in managing pediatric Crohn's disease, with evolving treatment options.
  • Further research, particularly comparative trials, is essential to optimize treatment selection and outcomes.
  • Consideration of new agents, biosimilars, and personalized treatment approaches is crucial.
Abstract

Keywords:
Crohn’s diseaseadalimumabbiologicsbiosimilarscost-benefitinfliximabpediatricustekinumabvedolizumab

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