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Mixing old and young: enhancing rejuvenation and accelerating aging
Ashley Lau1, Brian K Kennedy2,3,4,5, James L Kirkland6
1Division of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
The Journal of Clinical Investigation
|January 3, 2019
Summary
Donor and recipient age significantly impact transplant success. Young cells may rejuvenate, while old cells can accelerate aging, influencing outcomes in hematopoietic stem cell and solid organ transplantation.
Area of Science:
- Transplantation immunology
- Gerontology
- Cellular biology
Background:
- Donor and recipient age are critical factors affecting transplant outcomes.
- Age-related intrinsic graft function and immune responses play a role.
- Extrinsic cellular effects (rejuvenation or aging) from donor cells are also relevant.
Purpose of the Study:
- To review mechanisms of age-related cellular effects in transplantation.
- To discuss the clinical relevance of donor-recipient age discrepancies.
- To explore therapeutic intervention opportunities.
Main Methods:
- Review of recent scientific literature.
- Analysis of mechanisms of cellular rejuvenation and aging.
- Discussion of clinical implications in transplantation.
Main Results:
- Young cells can exert rejuvenating effects, while old cells can accelerate aging.
- These cellular effects are significant in hematopoietic stem cell and solid organ transplants.
- Age discrepancies between donor and recipient can exacerbate these effects.
Conclusions:
- Understanding cellular aging and rejuvenation mechanisms is crucial for improving transplant outcomes.
- Therapeutic strategies targeting these age-related cellular effects hold promise.
- Further research is needed to harness these findings for clinical application.
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