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Polycaprolactone Antimony Nanoparticles as Drug Delivery System for Leishmaniasis
Ariane de Jesus Sousa-Batista1, Cristal Cerqueira-Coutinho2, Fagner Santos do Carmo3
1Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
American Journal of Therapeutics
|January 3, 2019
Summary
Nanoparticles loaded with meglumine antimoniate show promise for treating visceral leishmaniasis by targeting infected organs. This novel approach may reduce side effects and improve treatment efficacy for this neglected tropical disease.
Area of Science:
- Nanomedicine
- Parasitology
- Drug Delivery
Background:
- Leishmaniasis affects 1.6 million people annually, with current treatments causing severe side effects and struggling to reach intracellular parasites.
- Existing treatments for leishmaniasis include pentavalent antimony, pentamidine, and amphotericin B, all with significant limitations.
Purpose of the Study:
- To evaluate nanoparticles loaded with meglumine antimoniate for targeted delivery in leishmaniasis.
- To assess if nanoantimony can reduce drug dosage and mitigate adverse effects in leishmaniasis treatment.
Main Methods:
- Nanoparticles (150-200 nm) loaded with meglumine antimoniate were prepared using double-emulsion solvent evaporation.
- Biodistribution of nanoantimony and meglumine antimoniate was assessed in BALB/c mice infected with Leishmania species using technetium-99m labeling.
Main Results:
- Biodistribution studies revealed preferential targeting of nanoantimony to the liver, spleen, and lungs, key organs affected by visceral leishmaniasis.
- A low uptake of nanoparticles was observed in the lesions of cutaneous leishmaniasis models.
Conclusions:
- The developed nanoparticles demonstrate potential for enhancing meglumine antimoniate efficacy in visceral leishmaniasis.
- This nanoparticle-based strategy offers a promising alternative therapeutic approach for leishmaniasis infections.
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