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Related Experiment Videos

'Third Space' Perspective on Redefining Oral Pathology: Hypothetical Considerations.

Shankargouda Patil1, Barnali Majumdar2, Sachin C Sarode3

  • 1Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Kingdom of Saudi Arabia.

The Journal of Contemporary Dental Practice
|January 4, 2019
PubMed
Summary

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Recent research suggests the human interstitium, a network of connective tissue, may be a new organ. This discovery has significant implications for understanding oral cancer metastasis and other oral diseases.

Area of Science:

  • Anatomy
  • Pathology
  • Oncology

Background:

  • Recent molecular analysis identifies the human interstitium as a potential new organ.
  • These fluid-filled spaces are often not visible in standard hematoxylin and eosin stained tissue sections.
  • This lack of visibility may explain why the interstitium has been overlooked in routine pathology.

Discussion:

  • The discovery of the interstitium as a distinct organ has profound implications for oral pathology, particularly in understanding oral cancer metastasis.
  • If confirmed in oral submucosa, this finding could necessitate a re-evaluation of various oral diseases linked to fluid dynamics.
  • This editorial explores the hypothetical implications of the 'third space' concept in dentistry.

Key Insights:

  • The interstitium's role in cancer metastasis, especially oral cancer, requires further investigation.

Related Experiment Videos

  • Understanding the interstitium's structure in oral mucosa could revolutionize the diagnosis and treatment of oral diseases.
  • The 'third space' may represent a critical, previously unrecognized component of oral tissue architecture.

    • Outlook:

    • Future research should focus on validating the interstitium's presence and function within the oral submucosa.
    • Investigating the interstitium's role in fluid transport could lead to novel therapeutic strategies for oral diseases.
    • This discovery opens new avenues for exploring the pathophysiology of oral cancer and other conditions.