Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Therapy00:59

Gene Therapy

27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
What is Genetic Engineering?00:49

What is Genetic Engineering?

80.1K
Overview
80.1K
Bone Cells and Tissue01:30

Bone Cells and Tissue

8.3K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
8.3K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.8K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.8K
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

4.2K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
4.2K
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

6.8K
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
6.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bilateral corneal perforation following post-PRK fungal keratitis managed with tenons patch graft.

BMJ case reports·2026
Same author

Ionic liquids as synergistic stabilizers in biopharmaceuticals: controlling protein aggregation in formulation and processing.

International journal of pharmaceutics·2026
Same author

A CHO-Derived Matrix Attachment Region Enhances Transgene Dosage, SATB1 Recruitment, and Monoclonal Antibody Expression in a Dual-Promoter Vector System.

Molecular biotechnology·2026
Same author

<i>Lactobacillus acidophilus</i> combined with <i>Pediococcus acidilactici</i> ameliorates colitis.

Frontiers in microbiology·2026
Same author

Recent Progress of Dopamine-Modified Tissue Adhesives for Biomedical Applications in Underwater Environments.

Tissue engineering and regenerative medicine·2026
Same author

Antioxidant excipient-mediated stabilization preserves FcγRIIIa binding and ADCC activity of rituximab.

Biologicals : journal of the International Association of Biological Standardization·2026

Related Experiment Video

Updated: Jan 31, 2026

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

4.1K

Gene therapy for bone tissue engineering.

Young-Dong Kim1, Prasad Pofali2, Tae-Eun Park3

  • 11Department of Molecular Genetics, School of Dentistry, Seoul National University, Seoul, Korea.

Tissue Engineering and Regenerative Medicine
|January 4, 2019
PubMed
Summary
This summary is machine-generated.

Gene therapy enhances bone regeneration by delivering osteogenic genes via various vectors and scaffolds. Both ex vivo and in vivo approaches show success in bone tissue engineering, improving bone formation.

Keywords:
Bone morphogenetic proteinBone tissue engineeringGene therapyNon-viral vectorViral vector

More Related Videos

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
09:49

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

2.7K
Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus AAV Capsid Variants
09:20

Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus AAV Capsid Variants

Published on: October 18, 2022

5.2K

Related Experiment Videos

Last Updated: Jan 31, 2026

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

4.1K
Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
09:49

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

2.7K
Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus AAV Capsid Variants
09:20

Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus AAV Capsid Variants

Published on: October 18, 2022

5.2K

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Gene Therapy

Background:

  • Gene therapy is a promising strategy for bone tissue engineering.
  • Osteogenic gene delivery aims to improve bone formation and regeneration.
  • Various vectors, scaffolds, and delivery methods are employed.

Purpose of the Study:

  • To review recent advances in gene therapy for bone tissue engineering.
  • To discuss the strengths and weaknesses of different gene therapy strategies.
  • To provide an overview of gene therapy applications in bone regeneration.

Main Methods:

  • Review of ex vivo and in vivo gene-enhanced tissue engineering approaches.
  • Analysis of viral and non-viral vector systems for gene delivery.
  • Evaluation of scaffold-based delivery methodologies.

Main Results:

  • Successful osteogenic differentiation and bone formation observed in gene-enhanced approaches.
  • Identification of diverse strategies combining genes, vectors, and scaffolds.
  • Assessment of the efficacy and limitations of current gene therapy techniques.

Conclusions:

  • Gene therapy offers significant potential for advancing bone tissue engineering.
  • A comprehensive understanding of various strategies is crucial for successful bone regeneration.
  • Continued research is needed to optimize gene therapy for clinical applications in bone repair.