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Updated: Jan 31, 2026
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Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
Published on: August 11, 2017
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Advances in three-dimensional bioprinting for hard tissue engineering.
Sang-Hyug Park1, Chi Sung Jung2,3, Byoung-Hyun Min2,3,4,5
11Department of Biomedical Engineering, Pukyong National University, Busan, Korea.
Tissue Engineering and Regenerative Medicine
|January 4, 2019
Summary
Three-dimensional (3D) bioprinting offers a promising alternative for organ and tissue regeneration, particularly for hard tissues like bone and cartilage. While challenges remain, this technology advances regenerative medicine by enabling the creation of complex artificial tissues.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Tissue Engineering
Background:
- Increasing demand for organ and tissue regeneration due to donor scarcity and transplant rejection.
- Artificial tissues are explored as alternatives to traditional transplantation.
- Three-dimensional (3D) bioprinting, an additive manufacturing technique, shows potential for fabricating functional tissues and organs.
Purpose of the Study:
- To review the current technical developments in 3D bioprinting for hard tissue engineering.
- To identify and discuss the challenges associated with 3D bioprinting of hard tissues.
- To explore the future prospects of 3D bioprinting in regenerative medicine.
Main Methods:
- Review of current literature and technical advancements in 3D bioprinting for hard tissue fabrication.
- Analysis of strategies and approaches used in 3D bioprinting of cartilage and bone.
- Identification of limitations and challenges in current 3D bioprinting methodologies.
Main Results:
- 3D bioprinting has demonstrated potential in fabricating transplantable hard tissues, including cartilage and bone.
- The technology can replicate the complex architecture of natural tissues.
- Significant technical challenges persist in realizing fully functional 3D engineered hard tissues.
Conclusions:
- 3D bioprinting is a key technology for regenerative medicine, with proven applications in hard tissue engineering.
- Overcoming current challenges is crucial for the clinical translation of 3D bioprinted hard tissues.
- Future research should focus on addressing technical hurdles to fully realize the potential of 3D bioprinting for organ and tissue regeneration.
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