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Related Concept Videos

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Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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A typical nerve cell comprises three main components: the cell body, dendrites, and the axon. The cell body, also known as the soma or perikaryon, serves as the central biosynthetic hub housing a nucleus surrounded by cytoplasm containing organelles commonly found in most cells. Notably, Nissl bodies, clusters of the rough endoplasmic reticulum and free ribosomes responsible for protein synthesis, are distinctive features of the neuronal cell body. As neurons age, aggregates of a brown pigment...
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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
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Selectins modify dendritic cells during atherosclerosis.

Zhi-Shuai Ye1, Rong-Chong Huang1

  • 1Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China.

Chronic Diseases and Translational Medicine
|January 4, 2019
PubMed
Summary
This summary is machine-generated.

Regulatory dendritic cells (DCs) can switch immune responses toward tolerance, crucial for managing atherosclerosis. This review explores their generation and the role of selectins in modifying DCs during this disease.

Keywords:
AtherosclerosisDendritic cellsImmune toleranceSelectins

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Area of Science:

  • Immunology
  • Cardiovascular Research
  • Cell Biology

Background:

  • Dendritic cells (DCs) are key antigen-presenting cells (APCs) involved in atherosclerosis.
  • DCs are a heterogeneous lineage with diverse functions and phenotypes.
  • Immature DCs can be modulated to induce regulatory functions and immune tolerance.

Purpose of the Study:

  • To review the current understanding of regulatory DC generation.
  • To discuss the role of DCs as regulators of immune responses in atherosclerosis.
  • To explore the novel involvement of selectins in DC modification within atherosclerosis.

Main Methods:

  • Literature review of immunology and cardiovascular research.
  • Analysis of DC heterogeneity and regulatory mechanisms.
  • Examination of selectin function in DC modulation.

Main Results:

  • Regulatory DCs are generated through specific immunosuppressive modulation.
  • DCs act as critical "switches" between immune activation and tolerance.
  • Selectins play a newly identified role in modifying DCs in atherosclerosis.

Conclusions:

  • Understanding regulatory DC generation is key to immune tolerance strategies.
  • DCs offer a potential therapeutic target for modulating immune responses in atherosclerosis.
  • Selectins represent a novel area of investigation for atherosclerosis treatment.