Related Experiment Video

Updated: Jan 31, 2026

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
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A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

681

Association between Circulatory and Plaque Resistin Levels with Carotid Plaque Instability and Ischemic Stroke Events

Ivana Jurin1, Frane Paić2,3, Stela Bulimbašić4

  • 1Department of Cardiovascular Diseases, University Hospital Dubrava, Avenija Gojka Šuška 6, 10 000 Zagreb, Croatia.

The Heart Surgery Forum
|January 4, 2019
PubMed

Insights

Higher resistin levels in blood and carotid plaques are linked to unstable plaques and ischemic stroke events. Resistin may serve as a biomarker for stroke risk in patients with carotid artery stenosis.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Biomarker Research

Background:

  • Ischemic stroke risk correlates with carotid stenosis severity and plaque vulnerability.
  • Identifying biomarkers for plaque instability and stroke is crucial for patient management.

Purpose of the Study:

  • To investigate the association between circulating and plaque resistin levels with carotid plaque vulnerability and ischemic stroke events.
  • To explore resistin's role as a potential biomarker in patients with moderate- to high-grade carotid artery stenosis.

Main Methods:

  • Recruited 40 ischemic stroke patients and 38 asymptomatic patients undergoing carotid endarterectomy.
  • Measured serum resistin via ELISA and plaque resistin expression via immunohistochemistry.
  • Histologically classified carotid endarterectomy specimens.

Main Results:

  • Significantly higher serum and plaque resistin levels were observed in patients with unstable carotid plaques and ischemic stroke events.
  • Higher serum resistin levels were independently associated with plaque instability and ischemic stroke.
  • Resistin levels correlated with specific histological features of plaque instability.

Conclusions:

  • Serum resistin levels may serve as a potential biomarker for plaque vulnerability and ischemic stroke in patients with carotid artery stenosis.
  • Plaque resistin expression is associated with histological indicators of plaque vulnerability.

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