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Updated: Jan 31, 2026

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 25, 2016
Prestin autoantibodies screening in idiopathic sudden sensorineural hearing loss
H Tovi1, H Ovadia2, R Eliashar1
1Department of Otolaryngology-Head & Neck Surgery, Hadassah Hebrew-University Hospital, 91120 Jerusalem, Israel.
Objectives:
To define the clinical association of serum prestin autoantibodies and their impact on prognosis, as specific serum diagnostic markers in patients with idiopathic sudden sensorineural hearing loss (ISSNHL).
Design:
Sera from 63 patients with ISSNHL were screened prospectively for the presence of prestin autoantibodies by an enzyme-linked immunosorbent assay (Elisa) test. Serum was assayed for anti-prestin IgG antibodies using recombinant human prestin (SLC26 A5). Demographic, clinical, and audiometric variables were analyzed.
Results:
Two patients (3.17%) had demonstrable anti-prestin antibodies in serum (exact 95% CI: -1.16% to 7.5%). No statistically significant association was found between prestin autoantibodies and demographic or audiologic parameters.
Conclusions:
This preliminary and novel study does not support the presence of an active humoral immune reaction against prestin in ISSNHL.
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