Molecular mechanism of steroid hormone action during aging. A review

The application of immunochemistry coupled with genetic engineering techniques has helped greatly in the understanding of the molecular mechanism of steroid hormone action. Particularly, the recent observations on nuclear localization of steroid receptor proteins and the interaction of the steroid-receptor complex with the genome have provided much insight into the whole pathway of steroid hormone action. Despite the large amount of data accumulated over the years on the mechanism of steroid action in general, relatively little is known about the changes occurring in the action of steroid hormones during aging. However, there is some evidence of a decreased responsiveness of target tissues to steroid hormones during senescence. In the light of recent progress in steroid research, an attempt has been made in this article to discuss the alterations that occur at different steps of steroid action as a function of age.