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Updated: Jan 31, 2026

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[Acute myelitis associated with anti-neutral glycolipid antibody]

Hideo Terasawa1, Hirotaka Shimuzu1, Toshiyuki Uehara1

  • 1Department of Neurology, Hyogo Brain and Heart Center at Himeji.

Rinsho Shinkeigaku = Clinical Neurology
|January 5, 2019
PubMed

Insights

Acute myelitis can be linked to anti-neutral glycolipid antibodies, specifically anti-lactosylceramide (LacCer) antibodies. Testing for these antibodies is recommended for patients with myelitis.

Area of Science:

  • Neurology
  • Immunology
  • Neuroimmunology

Background:

  • Acute myelitis is a neurological condition characterized by inflammation of the spinal cord.
  • Differential diagnosis of myelitis includes autoimmune disorders and infections.
  • Standard autoimmune markers like anti-aquaporin-4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) antibodies are often tested.

Observation:

  • A 48-year-old male presented with acute myelitis and a T2-hyperintense spinal cord lesion.
  • Initial serological tests for collagen diseases, AQP4, and MOG antibodies were negative.
  • Anti-lactosylceramide (LacCer) antibodies were detected during the acute phase and decreased during recovery.

Findings:

  • The patient's symptoms resolved with immunotherapy.
  • The presence of anti-LacCer antibodies suggests a role for anti-neutral glycolipid antibodies in myelitis.
  • Titers of anti-LacCer antibodies correlated with disease activity.

Implications:

  • This case highlights anti-neutral glycolipid antibodies as a potential cause of acute myelitis.
  • Routine screening for anti-neutral glycolipid antibodies may be warranted in unexplained myelitis cases.
  • Further research into anti-glycolipid antibody-associated neurological disorders is suggested.
Keywords:
acute disseminated encephalomyelitis (ADEM)anti-neutral glycolipid antibodymyelitis

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