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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
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Systematic screening for occupations and occupational exposures in head and neck squamous cell carcinoma patients

Sophie Deneuve1,2, Barbara Charbotel3,4, Amélie Massardier-Pilonchéry3,4

  • 1Oncologic Surgery Department, Léon Bérard Center, 28 Rue Laennec, 69008, Lyon, France. sophie.deneuve@lyon.unicancer.fr.

European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|January 5, 2019
PubMed
Abstract

Insights

Occupational exposures, including asbestos, solvents, and silica, are common in head and neck squamous cell carcinoma (HNSCC) patients. Physicians should pay more attention to these workplace risks.

Area of Science:

  • Oncology
  • Occupational Health
  • Epidemiology

Background:

  • Occupational exposures are increasingly recognized as potential contributors to various cancers.
  • The role of workplace exposures in head and neck squamous cell carcinomas (HNSCC) has been historically under-investigated.

Purpose of the Study:

  • To systematically characterize occupational exposures in patients diagnosed with HNSCC.
  • To investigate the association between common occupational exposures and HNSCC characteristics such as stage and tumor location.

Main Methods:

  • A prospective, single-center study involving 154 HNSCC patients.
  • Detailed occupational history and consultation to identify workplace exposures.
  • Statistical analysis to determine associations between exposures and HNSCC features.

Main Results:

  • Patients reported an average of 3.3 occupations throughout their careers.
  • Asbestos exposure was prevalent (29.9%), exceeding rates in the general French population over 50.
  • Solvents (16.9%) and silica (12.3%) were also frequent exposures; 24% of patients had a potential occupational exposure link to HNSCC.
  • Longer asbestos exposure duration correlated with hypopharyngeal and laryngeal cancer.

Conclusions:

  • Occupational exposures are a significant factor in a notable percentage of HNSCC cases.
  • Increased physician awareness and systematic evaluation of occupational history are crucial for HNSCC patients.
Keywords:
AsbestosEnvironmental exposureHead and neck squamous cell carcinomaOccupational exposureProfessional disease

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