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Updated: Jan 31, 2026
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Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs
Published on: August 15, 2025
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Mohs Micrographic Surgery: Past, Present, and Future
Diana K Cohen1, David J Goldberg1,2
1Skin Laser & Surgical Specialists of NY and NJ, Hackensack, New Jersey.
Summary
Mohs micrographic surgery (MMS) effectively treats various skin neoplasms, showing superiority over surgical excision for recurrent nonmelanoma skin cancer. Future advancements include integrating imaging and digital technologies for enhanced outcomes.
Area of Science:
- Dermatology
- Surgical Oncology
Background:
- Mohs micrographic surgery (MMS) is a specialized surgical technique offering complete margin assessment for skin neoplasms.
- Its widespread adoption accelerated in the 1970s with the advent of the fresh frozen technique.
Purpose of the Study:
- To comprehensively review the literature on Mohs micrographic surgery (MMS).
- Focus areas include the historical origins, current evidence supporting its use, and future directions for the technique.
Main Methods:
- A systematic literature search was performed using PubMed.
- Articles relevant to Mohs micrographic surgery (MMS) were identified and analyzed.
Main Results:
- Randomized controlled trials and prospective studies confirm low recurrence rates for nonmelanoma skin cancer (NMSC) treated with MMS.
- MMS demonstrated a statistically significant higher cure rate compared to surgical excision for recurrent NMSC.
- Low recurrence rates were also observed for melanoma and melanoma in situ treated with MMS, alongside efficacy in rare cutaneous neoplasms.
Conclusions:
- Mohs micrographic surgery (MMS) is a highly effective treatment for numerous skin neoplasms.
- It offers statistically significant advantages over surgical excision for recurrent and high-risk NMSC.
- The future of MMS will likely involve advancements in noninvasive imaging, immunostaining, and digital technologies.
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