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Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays
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A colorimetric assay system for dopamine using microfluidic paper-based analytical devices.

Chunye Liu1, Frank A Gomez2, Yanqing Miao1

  • 1School of Pharmacy, Xi'an Medical University, Xi'an 710021, China.

Talanta
|January 6, 2019
PubMed
Summary
This summary is machine-generated.

We developed a colorimetric method for detecting dopamine (DA) using microfluidic paper-based analytical devices (μPADs). This rapid, low-cost technique accurately quantifies DA in real samples like blood serum.

Keywords:
ColorimetryDopamineMicrofluidic paper-based analytical devicesOxidation-reduction

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Area of Science:

  • Analytical Chemistry
  • Biomedical Engineering

Background:

  • Dopamine (DA) is a crucial neurotransmitter implicated in various physiological and pathological processes.
  • Accurate and accessible detection methods for DA are essential for clinical diagnostics and research.

Purpose of the Study:

  • To develop and validate a novel colorimetric method for dopamine detection.
  • To utilize microfluidic paper-based analytical devices (μPADs) for rapid and low-cost analysis.
  • To assess the method's performance in real biological samples.

Main Methods:

  • Fabrication of μPADs using wax printing.
  • Colorimetric detection of dopamine via an oxidation-reduction reaction with ferric chloride and phenanthroline.
  • Quantification of color intensity using a cell phone camera and Photoshop analysis.

Main Results:

  • Achieved a limit of detection (LOD) for DA of 0.37 μmol/L.
  • Established a linear detection range of 0.527–4.75 μmol/L.
  • Demonstrated high precision with inter-day (0.11%) and intra-day (0.15%) relative standard deviations.
  • Successfully detected DA in cow serum, human blood serum, and plasma samples.

Conclusions:

  • The developed μPAD-based colorimetric method offers a sensitive, rapid, and cost-effective approach for dopamine detection.
  • This technique shows significant potential for application in real-world clinical and research settings.
  • The use of common cell phones for detection enhances accessibility and portability.