Animal models in the pathogenesis and treatment of rabies

Various animal models have been developed for the study of the pathogenesis of rabies and of methods for halting its spread. The long incubation period and the relatively low mortality observed in human rabies can be mimicked by injecting mice in the footpad with rabies virus. To relate the immune response and efficacy of treatment to the situation in humans, however, it is necessary to corroborate the results in rodents with those in subhuman primates. Methods effective and safe in subhuman primates may be considered for use in humans.