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Updated: Jan 31, 2026

Genotyping of Sea Anemone during Early Development
Published on: May 13, 2019
A Phenotypically Unusual Hemoglobin H Disease Resulting from a Rare α-Globin Genotype (-SEA/-α27.6)
Li-Qin Ling1, Hao Chen1, Song-Liang Yu1
1Department of Laboratory Medicine, West China School of Medicine/West China Hospital, Sichuan University, Chengdu, China.
Abstract:
Hemoglobin H (Hb H) disease is usually characterized by the existence of Hb H, which influences the degree of functional anemia. We here report a patient with a rare Hb H disease genotype (-SEA/-α27.6), who was observed to paradoxically have no detectable Hb H fraction on electrophoresis. To date, the reason why the quantity of Hb H component and the clinical presentation in Hb H disease vary widely is still incompletely understood. Our report demonstrates a possible explanation - the different degradation ability of excess β-globin chains, which might be regulated by the 27.6 kb sequence of α-globin gene.
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