Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug01:14

Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug

228
In pharmacotherapy, monitoring drug concentrations is paramount, especially for drugs whose therapeutic effects hinge on both the active compound and its metabolite. Hepatic impairment profoundly influences drug potency by altering liver function. If the drug is more potent than its metabolite, impaired liver function amplifies drug activity due to elevated drug concentration levels. Conversely, if the metabolite holds greater potency, diminished liver function diminishes drug activity by...
228
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

1.8K
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
1.8K
Biological Effects of Radiation02:59

Biological Effects of Radiation

17.9K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
17.9K
What is Conservation Biology?01:57

What is Conservation Biology?

24.3K
Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials.
24.3K
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship01:29

Cholinergic Antagonists: Chemistry and Structure-Activity Relationship

2.8K
Cholinergic antagonists bind to cholinergic receptors and limit the effects of acetylcholine and other cholinergic agonists. Based on the specific cholinergic receptor affinity, these antagonists are classified as muscarinic or nicotinic. Anticholinergics interrupt parasympathetic innervations while sympathetic innervations remain uninterrupted. Muscarinic antagonists are also called 'muscarinic antagonists', 'antimuscarinics', or 'parasympatholytics'. Nicotinic...
2.8K
Adrenergic Agonists: Chemistry and Structure-Activity Relationship01:16

Adrenergic Agonists: Chemistry and Structure-Activity Relationship

3.9K
Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cultivation System Dominates Cucumber Performance and Root-Zone Microbiomes Across Biochar Particle Sizes.

Plants (Basel, Switzerland)·2026
Same author

Borate-Bridged Protolipids: A Prebiotic Route to Abiotic Membranes.

Life (Basel, Switzerland)·2026
Same author

Denitrogenative N-O Coupling of Benzyl Azides with <i>N</i>-Hydroxyphthalimide Mediated by Cerium(IV) Ammonium Nitrate as an Oxidant.

The Journal of organic chemistry·2026
Same author

Boron's Double Edge-Antibiotics, Toxins, and the Fine Line Between Them.

Molecules (Basel, Switzerland)·2026
Same author

Life with Boron: Steroid Architecture and the Chemistry of Marine Boronosteroids.

Marine drugs·2026
Same author

Steroidal Compounds at the Crossroads of Inflammation and Cancer: Implications for Drug Discovery and Therapy.

Biomedicines·2026

Related Experiment Video

Updated: Jan 31, 2026

Measurement of Chitinase Activity in Biological Samples
03:32

Measurement of Chitinase Activity in Biological Samples

Published on: August 22, 2019

10.8K

Oxetane-containing metabolites: origin, structures, and biological activities.

Vera Vil1, Alexander O Terent'ev1, Abed Al Aziz Al Quntar2

  • 1N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow, Russia, 119991.

Applied Microbiology and Biotechnology
|January 6, 2019
PubMed
Summary

Oxetane-containing compounds (OCC) are natural products with diverse biological activities. These high-energy heterocycles show promise as pharmacophores, with significant antineoplastic, antiviral, and antifungal properties.

Keywords:
ActivitiesAlgaeCyclobutaneFungiInvertebratesMicroorganismsOxetanePlant

More Related Videos

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
16:03

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms

Published on: January 11, 2015

10.0K
Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
06:14

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

Published on: October 15, 2017

8.8K

Related Experiment Videos

Last Updated: Jan 31, 2026

Measurement of Chitinase Activity in Biological Samples
03:32

Measurement of Chitinase Activity in Biological Samples

Published on: August 22, 2019

10.8K
A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
16:03

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms

Published on: January 11, 2015

10.0K
Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
06:14

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

Published on: October 15, 2017

8.8K

Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Organic Chemistry

Background:

  • Oxetane-containing compounds (OCC) are oxygen-containing non-aromatic heterocycles.
  • Over 600 OCC are found in nature, produced by microorganisms, marine invertebrates, algae, and notably plants of the genus Taxus.
  • Oxetanes possess high energy and are of significant interest as potential pharmacophores.

Purpose of the Study:

  • To explore the biological activities of oxetane-containing compounds (OCC).
  • To highlight the potential of OCC as novel pharmacophores in drug discovery.
  • To summarize the natural occurrence and bioactivity spectrum of OCC.

Main Methods:

  • Literature review and analysis of existing data on OCC.
  • Identification and characterization of OCC from natural sources.
  • Assessment of reported biological activities, including antineoplastic, antiviral, antifungal, angiogenesis stimulation, respiratory analeptic, and antiallergic effects.

Main Results:

  • OCC are widely distributed in nature, with a high prevalence in plants of the genus Taxus.
  • Microbial-derived OCC, particularly from bacteria and Actinomycetes, exhibit significant antineoplastic, antiviral (arbovirus), and antifungal activities.
  • Strong evidence supports OCC as angiogenesis stimulators, respiratory analeptics, and antiallergic agents, with confidence levels ranging from 81% to 99%.

Conclusions:

  • Oxetane-containing compounds represent a promising class of natural products with a broad range of valuable biological activities.
  • The unique structure and high-energy nature of oxetanes make them attractive scaffolds for developing new therapeutic agents.
  • Further research into OCC could lead to the discovery of novel drugs for various medical conditions, including cancer and viral infections.