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Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

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Published on: February 22, 2019

Urologic conditions associated with malignancy.

Eric M Lo¹, James M Hotaling², Alexander W Pastuszak²

¹Baylor College of Medicine, Houston, TX.

Urologic Oncology

|January 7, 2019

Summary

Benign urologic conditions like male infertility and Peyronie's disease share genetic links with various cancers. Further research aims to clarify these associations for improved cancer risk assessment and screening.

Keywords:

Cryptorchidism Hypospadias Male infertility Peyronie's disease Prostate cancer Testicular cancer

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Area of Science:

Urology
Oncology
Genetics

Background:

Cancer research increasingly highlights the role of genetics in malignancy.
Genetic dysregulation in cellular functions also impacts benign conditions, suggesting common underlying factors.
This shared genetic basis prompts investigation into links between urologic conditions and cancer risk.

Purpose of the Study:

To review existing literature connecting benign urologic conditions with malignancy.
To evaluate associations between male infertility, Peyronie's disease, cryptorchidism, and hypospadias, and various cancers.

Main Methods:

A comprehensive PubMed search was conducted using relevant keywords.
Studies were systematically assessed for quality, relevance, and study design.
Inclusion criteria focused on the relationship between urologic conditions and malignancy.

Main Results:

38 out of 52 evaluated studies were included in the review.
Associations were found between male infertility and testicular, prostate, melanoma, bladder, and thyroid cancers.
Common genetic alterations implicated in both male infertility and carcinogenesis were identified.

Conclusions:

The review confirms associations between several malignancies and benign urologic conditions.
While genetic and molecular mechanisms are proposed, causal links remain unproven.
Future research will focus on defining these relationships to aid in risk stratification and screening.