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Alarin in different human intestinal epithelial cell types.

Samir Jabari1, Falk Schrödl2,3, Alexandra Kaser-Eichberger2,3

  • 1Institute of Neuropathology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany. samir.jabari@fau.de.

Histochemistry and Cell Biology
|January 7, 2019
PubMed
Summary
This summary is machine-generated.

Alarin (AL) is found in human intestinal cells, including Paneth cells in the small intestine and various enteroendocrine cells in the large intestine. This distribution suggests AL

Keywords:
AlarinEnteroendocrine cellsEpithelial cellsGalanin familyPaneth cells

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Area of Science:

  • Gastroenterology
  • Neuroendocrinology
  • Cell Biology

Background:

  • Alarin (AL), a galanin family member, is found in the central nervous system and influences food intake.
  • Its distribution and function in the human intestine remain largely uncharacterized.

Purpose of the Study:

  • To investigate the immunohistochemical distribution of Alarin (AL) in human intestinal epithelia.
  • To determine the co-localization of AL with specific cell markers in the small and large intestines.

Main Methods:

  • Immunohistochemical staining of 12 human bowel tissue cryosections.
  • Double staining for AL and α-defensin 5 (αD).
  • Quadruple staining for AL with chromogranin (CG), synaptophysin (SY), somatostatin (SO), Peptide Y (PY), and 5-hydroxytryptamine (5-HT).
  • Quantitative co-localization analysis of digitized slides.

Main Results:

  • In the small intestine, 56% of AL-positive cells were identified as αD-positive Paneth cells.
  • AL was co-localized with SY and CG in approximately 27% of cells, suggesting enteroendocrine cells.
  • In the large intestine, AL was frequently co-localized with CG, 5-HT, and PY in enteroendocrine cells.

Conclusions:

  • Alarin (AL) is present in both Paneth cells and various enteroendocrine cells throughout the human intestine.
  • The distribution suggests AL may play roles in diverse physiological and pathological intestinal processes.