Oscillations and Spike Entrainment
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Updated: Jan 31, 2026

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
Published on: June 29, 2018
Charles J Wilson1, Matthew H Higgs1, DeNard V Simmons1
1Department of Biology, University of Texas at San Antonio, San Antonio, TX, 78249, USA.
Abstract:
Oscillatory input to networks, as indicated by field potentials, must entrain neuronal firing to be a causal agent in brain activity. Even when the oscillatory input is prominent, entrainment of firing is not a foregone conclusion but depends on the intrinsic dynamics of the postsynaptic neurons, including cell type-specific resonances, and background firing rates. Within any local network of neurons, only a subset of neurons may have their firing entrained by an oscillating synaptic input, and oscillations of different frequency may engage separate subsets of neurons.
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