Advances in delivery systems for doxorubicin
Na Zhao1, Martin C Woodle2, A James Mixson1
1Department of Pathology, University Maryland School of Medicine, 10 S. Pine St., University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.
Journal of Nanomedicine & Nanotechnology
|January 8, 2019
Summary
Liposomal doxorubicin formulations offer improved safety and efficacy over conventional chemotherapy. However, overcoming multidrug resistance remains a challenge for these advanced drug delivery systems.
Area of Science:
- Oncology
- Pharmacology
- Biomedical Engineering
Background:
- Doxorubicin is a vital chemotherapy drug, but its use is limited by cardiotoxicity and nephrotoxicity.
- Liposomal carriers, many FDA-approved, have been developed to mitigate doxorubicin's side effects.
- These liposomal formulations demonstrate comparable or superior antitumor efficacy and improved safety via the EPR effect.
Purpose of the Study:
- To review the development of doxorubicin drug delivery systems.
- To highlight improvements in therapeutic window (efficacy and safety).
- To address limitations of current FDA-approved doxorubicin formulations, particularly in multidrug-resistant tumors.
Main Methods:
- Review of existing literature on doxorubicin formulations and drug delivery systems.
- Analysis of liposomal carrier development and their interaction with tumor microenvironments.
- Evaluation of strategies to overcome multidrug resistance in doxorubicin therapy.
Main Results:
- Liposomal doxorubicin exhibits enhanced tumor accumulation through the EPR effect, improving safety.
- Approved liposomal doxorubicin preparations match or surpass conventional doxorubicin's antitumor efficacy.
- Current liposomal formulations struggle with efficacy against multidrug-resistant tumors.
Conclusions:
- Liposomal drug delivery systems have significantly advanced doxorubicin therapy by improving safety and efficacy.
- Further research is needed to develop doxorubicin formulations that effectively target multidrug-resistant cancers.
- Optimizing delivery systems is crucial for expanding the therapeutic applications of doxorubicin.
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