Related Experiment Video

Updated: Jan 31, 2026

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

10.4K

Interleukin-4 -590C/T gene polymorphism in Egyptian children with acute lower respiratory infection: A multicenter

Ahmed A Emam1, Mohamed M M Shehab1, Mayy A N Allah1

  • 1Department of Pediatrics, Faculty of Medicine, Zagazig University, Egypt.

Pediatric Pulmonology
|January 8, 2019
PubMed

Insights

The interleukin 4 (IL-4) gene -590C/T polymorphism is linked to increased susceptibility to acute lower respiratory infections (ALRIs) in Egyptian children. This genetic marker may play a role in ALRI development and severity.

Area of Science:

  • Genetics and Immunology
  • Pediatric Infectious Diseases

Background:

  • Acute lower respiratory infection (ALRI) is a primary cause of mortality in children, particularly in developing nations.
  • Interleukin 4 (IL-4) gene polymorphisms have been associated with various human diseases.

Purpose of the Study:

  • To determine if the IL-4 -590C/T (rs2243250) polymorphism serves as a genetic marker for ALRI susceptibility in young Egyptian children.
  • To investigate the association between IL-4 gene polymorphism and serum IL-4 levels in children with ALRI.

Main Methods:

  • A multicenter study involving 480 children with pneumonia or bronchiolitis and 480 healthy controls.
  • Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype the IL-4 -590C/T (rs2243250) single nucleotide polymorphism.
  • Serum IL-4 concentrations were quantified using enzyme-linked immunosorbent assay (ELISA).

Main Results:

  • The IL-4 -590 T/T genotype and T allele were significantly more frequent in children with ALRI compared to controls (OR=2.0 for T/T genotype; OR=1.3 for T allele; P<0.01).
  • The IL-4 -590 T/T genotype was associated with substantially higher mean serum IL-4 levels (58.7 pg/mL) than the C/T (47.6 pg/mL) and C/C (34.8 pg/mL) genotypes (P<0.01).

Conclusions:

  • The IL-4 -590C/T (rs2243250) polymorphism is a potential genetic factor contributing to susceptibility to acute lower respiratory infections in young Egyptian children.
  • This polymorphism may influence ALRI risk and disease severity through its impact on IL-4 production.
Abstract

Keywords:
acute lower respiratory infectionschildrengene polymorphisminterleukin 4

More Related Videos

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

17.6K
Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection07:36

Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection

Published on: February 28, 2021

3.5K

Related Concept Videos

Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
1000
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.1K
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
499
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
874
Acute Respiratory Failure-IV01:23

Acute Respiratory Failure-IV

Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
563
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
398