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Related Concept Videos

Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

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The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Gene Therapy00:59

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
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Related Experiment Video

Updated: Jan 31, 2026

Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making
11:51

Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making

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Testosterone, testosterone therapy and prostate cancer.

A Yassin1, K AlRumaihi2, R Alzubaidi2

  • 1Institute of Urology & Andrology , Norderstedt-Hamburg , Germany.

The Aging Male : the Official Journal of the International Society for the Study of the Aging Male
|January 8, 2019
PubMed
Summary
This summary is machine-generated.

Testosterone is no longer considered a direct cause of prostate cancer. Current research supports testosterone therapy for hypogonadism, even in men with a history of prostate cancer.

Keywords:
Hypogonadismprostate cancerquality of lifetestosterone

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Area of Science:

  • Endocrinology
  • Oncology
  • Urology

Background:

  • Historically, high androgens were linked to prostate cancer risk due to castration effectiveness.
  • Early theories overlooked testosterone's role within physiological ranges in tumor development.

Purpose of the Study:

  • To review the historical concept of testosterone as a prostate cancer risk factor.
  • To compile current literature on testosterone and prostate cancer therapy.

Main Methods:

  • Literature review
  • Analysis of clinical evidence
  • Examination of mechanistic hypotheses

Main Results:

  • Clinical evidence since the 2000s refutes testosterone as a linear driver of prostate cancer.
  • Alternative models, like the saturation model, are now favored.
  • Understanding of testosterone deficiency's negative health impacts has grown.

Conclusions:

  • A paradigm shift has occurred, moving away from viewing testosterone as a prostate cancer inducer.
  • Testosterone therapy is now considered for symptomatic hypogonadism, even post-prostate cancer treatment.