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[The volatile fatty acids in children with dysfunction of biliary tract]

E S Akaizin, A E Akaizina

    Klinicheskaia Laboratornaia Diagnostika
    |January 8, 2019
    PubMed

    Insights

    Children with biliary tract dysfunction show altered volatile fatty acids in saliva, indicating potential bacterial imbalances. These salivary markers may aid in diagnosing pediatric biliary conditions.

    Area of Science:

    • Microbiology
    • Gastroenterology
    • Pediatrics

    Background:

    • Volatile fatty acids (VFAs) are bacterial metabolites reflecting gastrointestinal microflora status.
    • Dysbiotic alterations in gut microbiota are linked to various health conditions.

    Purpose of the Study:

    • To qualitatively determine volatile fatty acids in the saliva of children with biliary tract dysfunction.
    • To compare VFA profiles between children with and without biliary tract dysfunction.

    Main Methods:

    • Analysis of VFAs in saliva samples from 46 children (7-17 years) with biliary tract dysfunction and 34 healthy controls.
    • Qualitative detection of acetic, butyric, and isovaleric acids using gas-liquid chromatography (automated gas chromatograph 'Crystal deluxe 4000', capillary column 'HP-FFAP', flame ionizing detector).

    Main Results:

    • Children with biliary tract dysfunction exhibited a decreased anaerobic index.
    • Elevated levels of acetic and propionic acids, along with a higher sum of VFAs, were observed in the saliva of children with biliary tract dysfunction compared to healthy controls.

    Conclusions:

    • Bacterial metabolites, including VFAs, may play a role in the pathogenesis of biliary tract dysfunction in children.
    • Salivary VFA profiles offer potential as novel diagnostic criteria for pediatric biliary tract dysfunction.

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