Related Experiment Video
Updated: Jan 31, 2026

Organotypic Tissue Model Systems for Investigating Host-Pathogen Interactions In Vitro
Published on: March 28, 2025
Systems-based approaches for investigation of inter-tissue communication
Marcus M Seldin1, Aldons J Lusis2,3,4
1Departments of Medicine, University of California, Los Angeles, Los Angeles, CA 90095.
Abstract:
Secreted proteins serve as crucial mediators of many physiology processes, and beginning with the discovery of insulin, studies have revealed numerous context-specific regulatory networks across various cell types. Here, we review "omics" approaches to deconvolute the complex milieu of proteins that are released from the cell. We emphasize a novel "systems genetics" approach our laboratory has developed to investigate mechanisms of tissue-tissue communication using population-based datasets. Finally, we highlight potential future directions for these studies, discuss several caveats, and propose new ways to investigate modes of endocrine communication.
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