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Related Concept Videos

Quantitative Analysis01:12

Quantitative Analysis

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Quantitative analysis is a technique for measuring the amount of specific constituents in a sample. When the sample's composition is unknown, qualitative analysis is performed first to identify its components, which ensures that the correct substances are measured during the quantitative phase.
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-IV: Diagnostic and Management01:30

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Asthma: Pathogenesis and Management01:20

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Related Experiment Video

Updated: Jan 31, 2026

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection
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Uncontrolled asthma phenotypes defined from parameters using quantitative CT analysis.

Xiaoxian Zhang1, Tingting Xia2, Zhengdao Lai1

  • 1National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.

European Radiology
|January 9, 2019
PubMed
Summary

Quantitative CT scans identified three distinct phenotypes of uncontrolled asthma, revealing significant air trapping and airway remodeling in severe cases. These findings aid in stratifying patients and understanding disease progression.

Keywords:
Airway remodelingAsthmaPhenotypeTomography, X-ray computed

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Area of Science:

  • Pulmonary Medicine
  • Radiology
  • Medical Imaging

Background:

  • Asthma is a complex respiratory disease with various clinical presentations.
  • Quantitative CT (qCT) has potential for classifying asthma phenotypes, but its role is not fully understood.

Purpose of the Study:

  • To investigate the determination of uncontrolled asthma phenotypes using quantitative CT (qCT).

Main Methods:

  • Sixty-five patients with uncontrolled asthma (severe and non-severe) and 25 healthy controls underwent qCT scans.
  • Clinical, laboratory, and pulmonary function tests were performed on all participants.

Main Results:

  • Severe uncontrolled asthma showed smaller lumen area and greater wall area compared to healthy subjects.
  • Significant air trapping was observed in severe uncontrolled asthma and all uncontrolled asthma patients versus controls.
  • Three distinct CT-determined phenotypes were identified based on air trapping and airway remodeling severity.

Conclusions:

  • Severe uncontrolled asthma is characterized by pronounced air trapping and proximal airway remodeling.
  • CT-based air trapping indices correlate with disease duration, atopy, and lung function.
  • Identified CT phenotypes may reflect underlying disease mechanisms and aid in patient stratification.