Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Tumors in transgenic mice].

A N Ermilov, I N Shvemberger

Eksperimental'Naia Onkologiia

|January 1, 1988

Summary

Transgenic mice offer a valuable model for biological research. Certain genetically modified mice develop spontaneous tumors, aiding the study of oncogene roles in cancer development.

Related Experiment Videos

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Role of proteins in Fas-mediated apoptosis in tumor cells and lymphocytes co-cultured in vitro].

Voprosy onkologii·2007

Same author

[The RT-PCR-identified Fas and FasL expression and apoptosis in mouse hepatoma MH-22a and histiocytic sarcoma J-774 clonal lines coupled with in vitro cultivation with syngenic splenocytes].

Voprosy onkologii·2005

Same author

Genetic variability of the mouse hepatoma cells MH-22a revealed by RAPD-PCR-fingerprinting under different conditions of cultivation.

Experimental oncology·2005

Same author

[RAPD-polymerase chain reaction analysis of the genetic structure of tumor hepatocyte population MH-22A].

Voprosy onkologii·2003

Same author

[Apoptosis: role in normal ontogenesis and in pathologic conditions].

Voprosy onkologii·2002

Same author

[Clonal analysis of the heterogeneity of neoplastic hepatocytes].

Voprosy onkologii·2001

Area of Science:

Molecular biology
Cellular biology
Tissue biology

Context:

Transgenic mice are instrumental in modern biological research.
Studying molecular, cellular, and tissue-level biological problems.

Purpose:

To investigate the utility of transgenic mice in biological studies.
To demonstrate the spontaneous tumor development in specific transgenic mouse models.

Summary:

Transgenic mice with integrated oncogenes (c-myc, v-myc) and viral genes (T-ag SV40, BPV) exhibit spontaneous tumor formation.
These genetically modified mice serve as a model for understanding oncogene involvement in tumorigenesis.

Impact:

Provides a model system for studying oncogenesis.
Facilitates research into the molecular mechanisms of tumor development.