Related Experiment Video
Updated: Aug 12, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 11, 2013
[Study of the biotransformation of various antineoplastic agents using the Ames test]
Abstract:
The Ames test on indicator bacteria S. typhimurium TA 1950 and TA 100 and the differential spectrophotometry have shown that cytochrome P-450-dependent monooxygenases of mammalian liver participate in the metabolism of antitumour drugs (cyclophosphamide, thiophosphamide) and of nitrosomorpholine (promutagen). Data concerning prospidin indicate that microsomal liver enzymes either induce no metabolic transformations of this preparation or the formed metabolites possess the mutagenic activity similar to that of the parent compound.
Related Concept Videos
Physical Properties of Amines
Mutagenicity and Carcinogenicity
Toxicity Testing in Animals

