Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

663
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
663
5-Number Summary01:04

5-Number Summary

5.7K
In a dataset, the 5-number summary includes the minimum data value, the data value of the first quartile, the median data value or data value of the second quartile, the data value of the third quartile, and the maximum data value. These 5 data values can be visualized as a box and whisker plot.
In a box plot, the minimum and maximum data values represent the lower and upper whiskers in the graph, and the median is designated as the center of the box in the chart. The first quartile and third...
5.7K
Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

110.9K
Overview
110.9K
Internal Receptors01:31

Internal Receptors

74.6K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.6K
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

86.5K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
86.5K
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

132.0K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
132.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating the impact of microalgae powder on physicochemical and functional properties of hard candies.

Food science and biotechnology·2026
Same author

Targeting Cellular Senescence Enhances Post-Burn Wound Healing in Aged Mice.

Shock (Augusta, Ga.)·2026
Same author

Shock Synopsis December 2025.

Shock (Augusta, Ga.)·2026
Same author

Shock Synopsis March 2026.

Shock (Augusta, Ga.)·2026
Same author

High-Dose Intravenous Vitamin C and Mortality and Organ Dysfunction in Severe Burn Injury: The VICTORY Randomized Clinical Trial.

JAMA·2026
Same author

Shock Synopsis June 2026.

Shock (Augusta, Ga.)·2026

Related Experiment Video

Updated: Jan 31, 2026

Murine Model of Wound Healing
05:39

Murine Model of Wound Healing

Published on: May 28, 2013

67.4K

5-HT1A Receptor Function Makes Wound Healing a Happier Process.

Alia Sadiq1,2,3, Isabella Menchetti1, Ahmed Shah1,3

  • 1Sunnybrook Research Institute, Toronto, ON, Canada.

Frontiers in Pharmacology
|January 9, 2019
PubMed
Summary

Serotonin and its 5-HT1A receptor are crucial for skin wound healing. Targeting the 5-HT1A receptor may offer new treatments for improved skin repair and reduced scarring.

Keywords:
5-HT1A receptor5-Ht1a receptor knockout mice modelserotoninskin regenerationwound healing

More Related Videos

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
02:49

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes

Published on: February 23, 2024

2.0K
Mongolian Gerbils as an Animal Model of Wound Healing
07:54

Mongolian Gerbils as an Animal Model of Wound Healing

Published on: January 6, 2023

2.4K

Related Experiment Videos

Last Updated: Jan 31, 2026

Murine Model of Wound Healing
05:39

Murine Model of Wound Healing

Published on: May 28, 2013

67.4K
Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
02:49

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes

Published on: February 23, 2024

2.0K
Mongolian Gerbils as an Animal Model of Wound Healing
07:54

Mongolian Gerbils as an Animal Model of Wound Healing

Published on: January 6, 2023

2.4K

Area of Science:

  • Dermatology
  • Neuroscience
  • Immunology

Background:

  • Skin wound healing is a complex process involving cellular interactions and regulatory factors.
  • Endogenous serotonin (5-hydroxytryptamine, 5-HT) acts as a neurotransmitter and cytokine.
  • The serotonin 1A receptor (5-HTR1A) mediates downstream cellular effects, with known roles in tissue regeneration.

Purpose of the Study:

  • To investigate the role of the 5-HT1A receptor in the process of skin wound healing.
  • To assess the impact of 5-HT1A receptor deficiency and activation on excisional wound repair.

Main Methods:

  • Utilized an excisional punch biopsy model in 5-HT1A receptor knockout mice.
  • Administered a topical 5-HT1A receptor agonist [(R)-(+)-8-Hydroxy-DPAT hydrobromide] to assess its effects on wound healing.
  • Analyzed wound healing parameters, including inflammatory cell infiltration (F4/80 macrophages), wound area, scar size, and neovascularization.

Main Results:

  • 5-HT1A receptor knockout mice exhibited impaired skin healing with increased F4/80 macrophages, prolonging the inflammatory phase.
  • Topical application of the 5-HT1A receptor agonist significantly reduced wound area and scar size.
  • Treatment with the agonist also promoted improved neovascularization, indicating enhanced healing.

Conclusions:

  • Serotonin and the 5-HT1A receptor play a significant role in regulating skin wound healing.
  • The 5-HT1A receptor is a potential therapeutic target for improving skin healing outcomes.
  • Further research into 5-HT1A receptor modulation could lead to novel treatments for minimizing scarring.