Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

698
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
698
Frequency-dependent Selection01:21

Frequency-dependent Selection

23.9K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
23.9K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.5K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.5K
Drug Dependence01:17

Drug Dependence

1.7K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.7K
Contact-dependent Signaling01:19

Contact-dependent Signaling

47.0K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
47.0K
Temperature Dependence on Reaction Rate02:55

Temperature Dependence on Reaction Rate

89.0K
The Collision Theory
Atoms, molecules, or ions must collide before they can react with each other. Atoms must be close together to form chemical bonds. This premise is the basis for a theory that explains many observations regarding chemical kinetics, including factors affecting reaction rates.
The collision theory is based on the postulates that (i) the reaction rate is proportional to the rate of reactant collisions, (ii) the reacting species collide in an orientation allowing contact between...
89.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A shared multi-feature population code for sensory reliability across mouse visual cortex.

bioRxiv : the preprint server for biology·2026
Same author

Using neural networks to understand static and dynamic cues in facial expression recognition.

Vision research·2026
Same author

A Journey through Scaffolds: Indolines, Pyrrolidines, and Azetidines in the Quest for Inhaled DDR Inhibitors for IPF.

Journal of medicinal chemistry·2026
Same author

Using deep learning to enhance reporting efficiency and accuracy in degenerative cervical spine MRI.

The spine journal : official journal of the North American Spine Society·2025
Same author

Exploring neural architectures for simultaneously recognizing multiple visual attributes.

Scientific reports·2024
Same author

A landscape review to identify what matters to patients with thrombotic cardiovascular diseases and patient-reported outcome instruments which can be used to capture the patient experience.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2024

Related Experiment Video

Updated: Jan 31, 2026

Performing Behavioral Tasks in Subjects with Intracranial Electrodes
12:10

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

11.9K

Age-Dependent Performance on Pro-point and Anti-point Tasks.

Elijah K Li1,2, Shannon Lee1,2,3, Saumil S Patel4

  • 1Department of Neurobiology and Anatomy, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.

Frontiers in Psychology
|January 9, 2019
PubMed
Summary

Manual pointing tasks show age-dependent performance, mirroring eye movement patterns. These novel tablet-based tests may offer a practical way to track cognitive changes and detect neurological deficits.

Keywords:
cognitive controlcognitive developmentprefrontal cortexsaccadessensorimotor control

More Related Videos

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration
07:46

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Published on: June 18, 2018

12.6K
Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
08:46

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

16.0K

Related Experiment Videos

Last Updated: Jan 31, 2026

Performing Behavioral Tasks in Subjects with Intracranial Electrodes
12:10

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

11.9K
Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration
07:46

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Published on: June 18, 2018

12.6K
Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
08:46

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

16.0K

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Human Development

Background:

  • Prefrontal cortex changes are linked to behavioral shifts in adolescence and late adulthood.
  • Disruptions in the prefrontal cortex are early indicators of various developmental, neurological, and psychiatric disorders.
  • Goal-directed eye movements, like Anti-saccades, are sensitive indicators of prefrontal lobe function.

Purpose of the Study:

  • To investigate how age influences manual pointing performance using novel tablet-based tasks.
  • To establish a preliminary understanding of age-related manual pointing patterns.
  • To assess the potential of these tasks for tracking prefrontal cortex-related behavioral changes.

Main Methods:

  • Recruited 82 participants aged 10 to 63.
  • Utilized novel tablet-based pointing tasks modeled on eye movement tests.
  • Analyzed response times for stimulus-driven (Pro-point) and goal-directed (Anti-point) tasks.

Main Results:

  • Manual pointing responses demonstrated age dependency, with U-shaped curves peaking in late adolescence/early adulthood.
  • Age had a greater effect on response times in the Anti-point task compared to the Pro-point task.
  • The Pro-point task's U-shaped curve flattened around 45 years, while the Anti-point task continued to approximately 60 years.

Conclusions:

  • Manual pointing tasks exhibit age-related patterns similar to saccades, suggesting their utility in assessing prefrontal cortex function.
  • The dissociation in age effects between Pro-point and Anti-point tasks indicates independent development of associated brain circuitry.
  • Tablet-based pointing tasks offer a practical, inexpensive method for detecting neurological deficits and monitoring cognitive changes.