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Evolution of the Population Structure of Staphylococcus pseudintermedius in France

Marine Bergot1, Patricia Martins-Simoes1,2, Hélène Kilian3

  • 1Centre International de Recherche en Infectiologie (CIRI), Equipe Pathogénie des Staphylocoques, Faculté de Médecine Laennec, Lyon, France.

Frontiers in Microbiology
|January 9, 2019
PubMed

Insights

The prevalence of the dominant methicillin-resistant Staphylococcus pseudintermedius (MRSP) ST71 clone is declining in France. New MRSP lineages, ST258 and ST496, are emerging, with ST496 posing a significant threat due to its multi-resistant genotype.

Area of Science:

  • Veterinary microbiology
  • Canine infectious diseases
  • Antimicrobial resistance

Background:

  • Staphylococcus pseudintermedius is a key pathogen in dogs, causing various infections.
  • The emergence of methicillin-resistant S. pseudintermedius (MRSP) has limited treatment options.
  • Sequence type (ST)71 was previously the dominant MRSP clone in Europe.

Purpose of the Study:

  • To investigate the changing landscape of MRSP clones in France.
  • To characterize the genetic features, including resistance and virulence genes, of emerging MRSP lineages.
  • To assess the potential threat posed by new MRSP clones to canine health.

Main Methods:

  • Whole-genome sequencing of MRSP isolates.
  • Analysis of sequence types (STs) and their prevalence over time.
  • Comparative genomics to identify resistance and virulence gene patterns.

Main Results:

  • The prevalence of ST71 MRSP is decreasing in France.
  • The non-ST71 MRSP population is genetically diverse and generally more susceptible to antibiotics.
  • Emerging lineages ST258 and ST496 show increasing success in France.
  • ST71 and ST496 clusters are genetically homogenous, while ST258 is more diverse.
  • ST496 possesses a multi-resistant genotype, indicating a potential threat.

Conclusions:

  • The MRSP clonal landscape in France is shifting, with a decline in ST71 and the rise of ST258 and ST496.
  • While non-ST71 clones may offer more treatment flexibility, ST496 warrants close monitoring due to its resistance profile.
  • Further research is needed to understand the factors driving the success of ST258 and ST496.
Keywords:
MLSTMRSPST258ST496dog

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