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Related Concept Videos

Root Loci for Positive-Feedback Systems01:23

Root Loci for Positive-Feedback Systems

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The Hartley oscillator is a positive feedback system that sustains oscillations by feeding the output back to the input in phase, thereby reinforcing the signal. Positive feedback systems can be viewed as negative feedback systems with inverted feedback signals. In these systems, the root locus encompasses all points on the s-plane where the angle of the system transfer function equals 360 degrees.
The construction rules for the root locus in positive feedback systems are similar to those in...
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When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
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Updated: Jan 31, 2026

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Putative Loci Causing Early Embryonic Mortality in Duroc Swine.

Chunyan Zhang1, Michael D MacNeil2,3, Robert A Kemp4

  • 1Department of Agricultural, Food & Nutritional Sciences, University of Alberta, Edmonton, AB, Canada.

Frontiers in Genetics
|January 9, 2019
PubMed
Summary

Researchers identified genetic variants linked to prenatal lethality in Duroc pigs, which can reduce litter size. This discovery aids in developing breeding strategies to improve piglet survival and fertility.

Keywords:
650K SNP chipDuroc pigsfertilityhaplotype blockslethal recessive loci

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Area of Science:

  • Animal Genetics
  • Reproductive Biology
  • Quantitative Genetics

Background:

  • Recessive lethal alleles, though rare, can impact population genetics by reducing litter size.
  • Detecting these alleles is crucial for improving livestock breeding efficiency.

Purpose of the Study:

  • To identify putative recessive lethal variants in the Duroc pig breed.
  • To analyze their impact on reproductive traits like litter size and stillbirths.

Main Methods:

  • Utilized SNP genotyping data from 1359 Duroc boars and phenotype data from over 5300 litters.
  • Applied statistical analysis to detect significant associations between genetic markers and reproductive traits.

Main Results:

  • Identified a significant SNP on SSC14 associated with mummified fetuses, with no observed homozygous individuals.
  • Detected 152 haplotypes potentially harboring lethal mutations, with 21 negatively impacting traits.
  • Pinpointed chromosomal regions on SSC1, SSC3, SSC8, SSC9, SSC12, and SSC17 associated with reduced fertility and litter size.

Conclusions:

  • The study identified key genetic loci and candidate genes (e.g., TEX14, CYP26B1) linked to prenatal lethality in Duroc pigs.
  • Findings provide valuable information for breeding programs to mitigate losses and enhance piglet production.
  • Further research into these genes can offer new insights into pig reproductive functions.