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Updated: Jan 31, 2026

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography
Published on: January 17, 2020
Transition metal substituted sandwich-type polyoxometalates with a strong metal-C (imidazole) bond as anticancer
Hongxia Zhao1, Li Tao, Fengmin Zhang
1School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, Jiangsu, People's Republic of China. lbni@yzu.edu.cn gwdiao@yzu.edu.cn.
Abstract:
Two novel sandwich-type polyoxometalates {Na0.7M5.3(H2O)2(imi)2(Himi)(SbW9O33)2}6- (M = NiII (1), CoII (2), imi = imidazole) containing a strong M-Cimi bond were synthesized by a tetragonal cluster [Na2Sb8W36O132(H2O)4]22- {Sb8W36} precursor. Compound 1 was highly cytotoxic against gastric cancer cells by arresting the cell cycle in the S-phase and inducing cell apoptosis.
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