Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes
Fei Zhao1, Pinyi Li2, Xiaoyan Liu3
1Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, 168 Hua Guan Road, Chengdu 610052, China. zhaofei@cdu.edu.cn.
Abstract:
The addition of amide/sulfonamide bonds to alkynes is not only one of the most important strategies for the direct functionalization of carbon⁻carbon triple bonds, but also a powerful tool for the downstream transformations of amides/sulfonamides. The present review provides a comprehensive summary of amide/sulfonamide bond addition to alkynes, including direct and metal-free aminoacylation, based-promoted aminoacylation, transition-metal-catalyzed aminoacylation, organocatalytic aminoacylation and transition-metal-catalyzed aminosulfonylation of alkynes up to December 2018. The reaction conditions, regio- and stereoselectivities, and mechanisms are discussed and summarized in detail.
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