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Published on: January 19, 2016
Rh(III)-Catalyzed [4 + 1] Annulation of Benzamides with CF3-Ynones as a C1 Synthon: Access to CF3-Containing
Wentai Xue1, Shuang Wu2, Hongqing Xie2
1College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China.
Abstract:
The development of concise and efficient methods for the construction of CF3-substituted isoindolinones remains highly desirable yet challenging. Herein, CF3-ynones, a classical C2 or C3 synthon, are exploited for the first time as a novel C1 synthon, which undergoes a rhodium(III)-catalyzed chemo- and regiospecific [4 + 1] annulation with benzamides to synthesize functionalized CF3-substituted isoindolinones. This protocol is characterized by excellent chemo- and regioselectivities, a broad substrate scope, good functional group tolerance, and good to high yields.
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