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Targeting Multiple Receptors to Increase Checkpoint Blockade Efficacy

David J Zahavi1, Louis M Weiner2

  • 1Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Medical Center, 3800 Reservoir Rd NW, Washington, DC 20007, USA. djz8@georgetown.edu.

International Journal of Molecular Sciences
|January 10, 2019
PubMed

Insights

Immune checkpoint blockade therapy shows promise for cancer treatment. Combining therapies targeting multiple immune checkpoints or other receptors may improve patient responses and anti-tumor immunity.

Area of Science:

  • Immunology
  • Oncology
  • Cancer Therapeutics

Background:

  • Immune checkpoint blockade therapy is a significant advancement in cancer treatment.
  • Many patients exhibit limited responses to single immune checkpoint inhibitors.
  • Ongoing discovery of novel inhibitory and stimulatory immune checkpoints, alongside immunomodulatory roles of known receptors, highlights therapeutic complexity.

Purpose of the Study:

  • To explore strategies for enhancing anti-tumor immunity.
  • To investigate the potential of combining immune checkpoint inhibitors.
  • To assess the combination of immune checkpoint blockade with other receptor-targeted therapies.

Main Methods:

  • Review of current immune checkpoint blockade therapies.
  • Analysis of emerging inhibitory and stimulatory immune checkpoints.
  • Evaluation of immunomodulatory functions of receptors in cancer progression.

Main Results:

  • Monotherapy targeting a single immune checkpoint often yields limited patient responses.
  • Discoveries of new immune checkpoints and receptor functions expand therapeutic targets.
  • Maximizing pro-anti-tumor immunity while minimizing immunosuppression is key to immunotherapy success.

Conclusions:

  • Combining immune checkpoint targeted approaches offers a promising therapeutic strategy.
  • Integration with other receptor targets may further enhance treatment efficacy.
  • Future therapeutic regimens should consider combination strategies for improved cancer immunotherapy outcomes.
Keywords:
combination therapyimmune checkpointreceptor targets

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